张蕊，2010年在中国科学院西北高原生物研究所获得理学博士学位，现为鲁东大学园艺学院副教授，园艺学学硕导师、农艺与种业专硕导师。烟台市种业振兴专家库特聘专家；中国中药协会菌物药专业委员会常务委员。
研究方向聚焦于食药用真菌，带领学子们在桑黄、牛樟芝、柽柳核纤孔菌、灵芝等的活性物质世界中不断探索，分离、解析并评估其生物活性，旨在为人类健康开拓新的可能。科研之路得到了多方认可与支持：先后主持国家自然科学基金、山东省优秀中青年科学家奖励基金、烟台市重点研发计划、东西部协作项目、以及鲁东大学人才引进基金等项目，是科研能力坚实的体现；同时主持与企业的横向合作项目2项。迄今已发表学术论文40余篇，其中SCI论文26篇，这些成果既是过往思考的沉淀，也是迈向未来的基石。
  自2019年金秋鲁大园艺初启研途之门，作为导师已相继送别五位学子完成硕士毕业论文。近五年来，我们共发表18篇论文，其中11篇SCI论文，7篇北大核心期刊论文。尤为欣慰的是，五篇硕士毕业论文在盲审的严苛目光下，四篇收获双A的嘉誉，一篇取得A与B的优良成绩，更有三篇硕果被授予校级优秀毕业论文的荣光，其作者亦荣膺优秀毕业生称号。这片园林静待新的耕耘者，期待与你一同，在下一个季节里，种下属于你的学术之花。
联系方式：
Email：zhlrui@163.com 办公地址：鲁东大学北区18号楼212

主持项目情况：
1、国家自然科学基金（31200048） 鹅膏毒肽类毒素与RNA聚合酶II的相互作用的理论研究，2013-2015。
2、山东省优秀中青年科学家奖励基金（2011BSB01040）鹅膏毒肽类毒素与RNA聚合酶II的相互作用机制研究，2011-2014。
3、烟台市重点研发项目（2019XDHZ092）高品质深层发酵桑黄产品中活性物质的高效利用，20190101-20211231。
4、东西部协作科技项目(wskjdxbxm2022006)：巫山淫羊藿活性物质深共熔溶剂高效提取与残渣联产精炼，2022.02-2022.12。
5、鲁东大学优秀人才引进基金(LY2011017)几种药物与beta2肾上腺素受体相互作用的机制研究，2011-2014。
6、横向课题：一种生态溶剂的研发及其在药用菌活性物质提取中的应用，2025-2027。
近年来发表的主要论文（*为通讯作者）：
1.Mingxing Yu, Na Zhang, Xiaofeng Ma, Xiaoshuang Zhou, Shude Yang, Weihang Peng, Yin Li, Yuejun Mu, Xianhao Cheng, Rui Zhang*, Yongfei Ming*. Comprehensive Assessment of Secondary Metabolite Diversity and In Vitro Anti-Diabetic Properties in Sanghuangporus quercicola Cultured Under Different Conditions. Systems Microbiology and Biomanufacturing, 2026, 6:10.
2.Xiaoshuang ZHOU, Xiaofeng MA, Kai HUANG, Tianyu SHI, Qin TIAN, Tianli ZHANG, Shude YANG, Xianhao CHENG, Rui ZHANG*, Yongfei MING*, Optimized extraction and antioxidant activity of polysaccharides from Inonotus hispidus using three-phase partitioning, Chinese Journal of Analytical Chemistry, 2025, 53(12): 100609.
3.Xiaofeng Ma, Na Zhang, Shiyuan Yu, Tianyu Shi, Shude Yang, Xianhao Cheng, Yongfei Ming*, Rui Zhang*. Cultivation Method-Driven Aroma Diversification in Antrodia cinnamomea: GC-IMS and Bioelectronic Sensors Reveal Distinctive Volatile Fingerprints. Foods, 2025, 14, 2790.
4.于明星，黄瑜瑄，马晓凤，周晓双，高霞，程显好，明永飞，张蕊*．栎树桑黄降血脂作用的体外评价及网络药理学机制．菌物学报. 2025, 44(11): 250087.
5.Na Zhang#, Qi Cui#, Xiao-Feng Ma, Kai Huang, Qin Tian, Tian-Li Zhang, Guo-Chao Wu, Shu-De Yang, Xian Hao Cheng, Rui Zhang*, Yong-Fei Ming*. Non-Targeted Metabolomics Analysis of Metabolite Differences in Inocutis tamaricis Under Different Culture Conditions. Biomedical Chromatography, 2025, 39:e70113.
6.周晓双, 张 娜, 马晓凤, 郑 娜, 班小绳, 于思涵, 明永飞, 张 蕊* . 高效液相色谱法检测6种桑黄菌丝体中酚类物质的研究, 食品科技, 2024, 49(12): 299-305.
7.YongFei Ming，Yin Li，JianZhi Chu，XiaoShuang Zhou，YuXuan Huang，ShuDe Yang，YueJun Mu，Lin Wang，Rui Zhang*，XianHao Cheng*. Comparative analysis of metabolites and in vitro hypoglycemic activity of Taiwanofungus camphoratus cultured using various methods. Applied Biological Chemistry, 2024, 67 :40.
8.Qi Cui, YongFei Ming, Mingxing Yu, Fangrong Lou, ShuDe Yang, Guochao Wu, WeiHuan Li, Yin Li, Rui Zhang*,  XianHao Cheng*. Optimization of favonoids extraction from Inocutis tamaricis and biological activity analysis, Journal of Food Measurement and Characterization, 2023, 17: 5619– 5632.
9.楚建芝，郑娜，崔琪，李满鑫，李寅，伍国超，程显好，张蕊*. 网络药理学和分子对接技术研究桑黄类真菌对疾病的潜在作用机制. 菌物学报，2023，42(1): 365-382.
10.Shi-jie Zheng, Na Zheng, Meng-li Zhang, Fang-fang Wu, Shu-de Yang, Xian-hao Cheng, Hai-ying Bao*, Rui Zhang*. Probing the binding mechanism of the erbascoside and human serum albumin by fuorescence spectroscopy and molecular docking approach. Monatshefte für Chemie - Chemical Monthly, 2023, 154: 151-158
11.楚建芝, 崔 琪, 杨树德, 伍国超, 程显好, 图力古尔, 张 蕊*.蘑菇毒素毒性作用机制的研究进展. 中草药, 2022, 53(24): 7925-7932.
12.Lei Wang,Wei-Huan Li, Rui Zhang, Yu-Peng Ge, Shu-De Yang,  Wei Liu,  Qi-Ping Wu, Xian-Hao Cheng* Study on Characteristics of Triterpenoids and Hepatoprotective Effects of Fruit Body of Stout Camphor Mushroom, Taiwanofungus camphoratus (Agaricomycetes), Cultivated with Apple-Wood, International Journal of Medicinal Mushrooms, 2022, 24(7):53 – 65.
13.JianZhi Chu, YongFei Ming, Qi Cui, Na Zheng, ShuDe Yang, WeiHuan Li, Hongwei Gao, Rui Zhang* and XianHao Cheng* Efficient extraction and antioxidant activity of polyphenols from Antrodia cinnamomea, BMC Biotechnology, 2022, 22:9, 1-12;
14.Na Zheng, Yongfei Ming, Jianzhi Chu, Shude Yang, Guochao Wu, Weihuan Li, RuiZhang* and Xianhao Cheng* Optimization of Extraction Process and the Antioxidant Activity of Phenolics from Sanghuangporus baumii, Molecules, 2021, 26(13), 3850;
15.张孟丽, 陈慧慧, 郑世杰, 吴芳芳, 谭栀恩, 张蕊*. 鹅膏蕈氨酸与人血清蛋白相互作用的机制研究. 化学研究与应用，2021, 33(11): 2222-2227.
16.张孟丽, 杨树德, 刘宇, 吴芳芳, 王华丽, 张蕊* 茯苓酸与人血清白蛋白相互作用的荧光光谱及分子对接研究, 药物分析杂志, 2020, 40(12): 2141-2148.
17.Shijie Zheng, Shude Yang, Xianhao Cheng, Tolgor Bau, Yu Li, Rui Zhang*, Haiying Bao*. Fluorescence Spectroscopy and Molecular Docking Approach to Probe the Interaction between Dehydroeburicoic Acid and Human Serum Albumin, Advances in Microbiology, 2019, 9, 21-37
18.郑世杰，张蕊*，杨树德，图力古尔，李玉，包海鹰*．香菇中麦角钙化甾醇含量的测定及其在人体内的传输机制. 菌物学报，2019, 38(5): 739-752
19.Rui Zhang*, Yongfei Ming & Yongjun Liu, Long time molecular dynamic simulation on the agonist binding and activation of the β2-adrenergic receptor, Molecular Simulation, 2015, 41(7): 564-571
20.Wenyou Zhu, Yongjun Liu*, Rui Zhang., A QM/MM  study  of  the  reaction mechanism  of  (R)-hydroxynitrile  lyases  from Arabidopsis thaliana (AtHNL). Proteins, 2015, 83, 66-77.
21.张蕊*(通讯), 吴超仪, 刘宇, 杨树德, 程显好. 分子对接和荧光光谱法研究麦角甾醇与牛血清白蛋白的相互作用, 食品科学, 2015, 36(23): 38-42.
22.Xiang Sheng, Yongjun Liu*, Rui Zhang, A theoretical study of the catalytic mechanism of oxalyl-CoA decarboxylase, an enzyme for treating urolithiasis, Royal Society of Chemistry Advances, 2014, 4, 35777-35788.
23.Wenyou Zhu, Yongjun Liu*, Rui Zhang ,QM/MM study of the conversion mechanism of lysine to methylornithine catalyzed by methylornithine synthase (PyIB), Theoretical  Chemistry  Accounts, 2013, 132: 1385.
24.ZHANG Rui, DONG Li-hua, LING Bao-ping, Wang Zhi-guo, Liu Yong-jun*. Activation of β2-Adrenergic Receptor Induced by Three Catecholamine Agonists: a Docking and Molecular Dynamics Study, Chemical Research in Chinese Universities, 2012, 28(3), 493-499.
25.张蕊, 杨树德, 程显好, 包海鹰, 图力古尔*, 鹅膏毒肽与RNA聚合酶II相互作用的分子机制研究, 菌物学报, 2012, 31(5):727-735.
26.张蕊, 图力古尔*, 鹅膏毒肽与RNA聚合酶II相互作用的研究进展, 食用菌学报, 2012, 19(2), 111-116.  
27.Ru Qiao*, Rui Zhang, Weiqun Zhu, Peijun Gong, Lab simulation of profile modification and enhanced oil recovery with a quaternary ammonium cationic polymer, Journal of Industrial and Engineering Chemistry, 2012, 18, 111-115.
28.Rui Zhang, Zhiguo Wang, Baoping Ling, Yongjun Liu*, Chengbu Liu, Docking and molecular dynamics studies on the interaction of four imidazoline derivatives with potassium ion channel (Kir6.2), Molecular Simulation, 2010, 36(2), 166-174.
29.Baoping Ling, Rui Zhang, Zhiguo Wang, Yongjun Liu*, Changqiao Zhang, Chengbu Liu. Theoretical studies on the interaction of guanine riboswitch with guanine and its closest analogs, Molecular Simulation, 2010, 36(12), 929-938.
30.张蕊, 凌宝萍, 孟祥华, 王志国, 张长桥, 刘永军*, 刘成卜, 咪唑啉类药物与钾离子通道Kir6.2相互作用的分子对接研究, 高等学校化学学报, 2009, 30(11), 2266-2271.